How long do rbcs live

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What are the markers of circulating red cell senescence and in cells during storage and transfusion? For sure within the life span of red blood cells many cellular properties change leading to aged mixed cell populations in the circulation.

Although red blood cells seem to be genetically terminated by the time they become red blood cells there are surprisingly versatile remodeling processes happening during their life span. Blocking that process led to several indicators of impaired RBC clearance, including toxic levels of free iron and hemoglobin and signs of liver and kidney damage.

If overactive, it could remove too many RBCs, but if it's sluggish or otherwise impaired, it could lead to iron toxicity. Further study could provide us with details of how this mechanism occurs in the first place and help us understand how to harness or suppress it in various conditions. Materials provided by Massachusetts General Hospital. Note: Content may be edited for style and length.

Science News. On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. Nature Medicine , ; DOI: ScienceDaily, 18 July Massachusetts General Hospital. How the body disposes of red blood cells, recycles iron: Accumulation and removal of aged or damaged cells found to take place mostly in the liver, rather than the spleen.